Structure of PDB 8cx4 Chain A

Receptor sequence
>8cx4A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAP
WIEQEGPEYWDRETQISKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYG
CDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAA
RVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRWEP
3D structure
PDB8cx4 Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y7 T24 E45 R62 E63 I66 S67 D77 Y84 Y99 Y123 T143 K146 W147 V152 L156 Y159 E163 W167 Y171 Y7 T24 E45 R62 E63 I66 S67 D77 Y84 Y99 Y123 T143 K146 W147 V152 L156 Y159 E163 W167 Y171
Gene Ontology
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
Cellular Component
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0042612 MHC class I protein complex
GO:0098553 lumenal side of endoplasmic reticulum membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8cx4, PDBe:8cx4, PDBj:8cx4
PDBsum8cx4
PubMed36477533
UniProtA3F718

[Back to BioLiP]