Structure of PDB 8cvh Chain A

Receptor sequence
>8cvhA (length=326) Species: 33113 (Atropa belladonna) [Search protein sequence]
VSESFVAPLEKRAENDVPLGNDVPIIDLQQDHLVVVQQITKACQDFGLFQ
VINHGLPEKLMAETMDVCKEFFALPAEEKEKLQPKGEPAKFELPLEQKAK
LYVEGEQLEAFLYWKDTLAHGCHPLDEELVNSWPEKPATYREVVAKYSVE
VRKLTMRILDYICEGLGLKLGYFDNELSQIQMMLTNYYPPCPDPSSTLGS
GGHYDGNLITLLQQNLPGLQQLIAKWIAVEPIPTAFVVNLGLTLKVITNE
KFEGSIHRVVTNPTRDRVSIATFIGPDYSCTIEPAKELLSQDNPPLYKPY
SYAEFGEIYLSDKSDYDAGVKPYKIN
3D structure
PDB8cvh Structure of the L289F H6H cyclization ferryl-mimicking complex
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.11: hyoscyamine (6S)-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OVR A F103 E116 G220 F289 Y325 F91 E104 G206 F273 Y309
BS02 V A H217 D219 H273 H203 D205 H257
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
GO:0047998 hyoscyamine (6S)-dioxygenase activity
Biological Process
GO:0002238 response to molecule of fungal origin
GO:0009805 coumarin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8cvh, PDBe:8cvh, PDBj:8cvh
PDBsum8cvh
PubMed
UniProtQ9XJ43

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