Structure of PDB 8cve Chain A

Receptor sequence
>8cveA (length=324) Species: 33113 (Atropa belladonna) [Search protein sequence]
VSESFVAPLEKRAENDVPLGNDVPIIDLQQDHLVVVQQITKACQDFGLFQ
VINHGLPEKLMAETMDVCKEFFALPAEEKEKLQPKGEPAKFELPLEQKAK
LYVEGEQAFLYWKDTLAHGCHPLDEELVNSWPEKPATYREVVAKYSVEVR
KLTMRILDYICEGLGLKLGYFDNELSQIQMMLTNYYPPCPDPSSTLGSGG
HYDGNLITLLQQNLPGLQQLIAKWIAVEPIPTAFVVNLGLTLKVITNEKF
EGSIHRVVTNPTRDRVSIATFIGPDYSCTIEPAKELLSQDNPPLYKPYSY
AEFGEIYLSDKSDYDAGVKPYKIN
3D structure
PDB8cve Structure of the L289F H6H hydroxylation reactant complex
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.11: hyoscyamine (6S)-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H217 D219 H273 H201 D203 H255
BS02 HYO A F103 E116 L198 H217 G220 N221 F289 Y318 Y325 F91 E104 L182 H201 G204 N205 F271 Y300 Y307
BS03 AKG A N200 Y202 H217 H273 V275 R283 S285 F289 N184 Y186 H201 H255 V257 R265 S267 F271
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
GO:0047998 hyoscyamine (6S)-dioxygenase activity
Biological Process
GO:0002238 response to molecule of fungal origin
GO:0009805 coumarin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8cve, PDBe:8cve, PDBj:8cve
PDBsum8cve
PubMed
UniProtQ9XJ43

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