Structure of PDB 8cv8 Chain A

Receptor sequence
>8cv8A (length=325) Species: 33113 (Atropa belladonna) [Search protein sequence]
SESFVAPLEKRAENDVPLGNDVPIIDLQQDHLVVVQQITKACQDFGLFQV
INHGLPEKLMAETMDVCKEFFALPAEEKEKLQPKGEPAKFELPLEQKAKL
YVEGEQAFLYWKDTLAHGCHPLDEELVNSWPEKPATYREVVAKYSVEVRK
LTMRILDYICEGLGLKLGYFDNELSQIQMMLTNYYPPCPDPSSTLGSGGH
YDGNLITLLQQNLPGLQQLIEDAKWIAVEPIPTAFVVNLGLTLKVITNEK
FEGSIHRVVTNPTRDRVSIATLIGPDYSCTIEPAKELLSQDNPPLYKPYS
YAEFGEIYLSDKSDYDAGVKPYKIN
3D structure
PDB8cv8 Structure of the H6H hydroxylation reactant complex
ChainA
Resolution1.532 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.11: hyoscyamine (6S)-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H217 D219 H273 H200 D202 H256
BS02 AKG A N200 Y202 H217 H273 V275 R283 S285 N183 Y185 H200 H256 V258 R266 S268
BS03 HYO A F103 E116 L198 H217 G220 L289 Y318 Y325 F90 E103 L181 H200 G203 L272 Y301 Y308
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
GO:0047998 hyoscyamine (6S)-dioxygenase activity
Biological Process
GO:0002238 response to molecule of fungal origin
GO:0009805 coumarin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8cv8, PDBe:8cv8, PDBj:8cv8
PDBsum8cv8
PubMed
UniProtQ9XJ43

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