Structure of PDB 8cuy Chain A

Receptor sequence
>8cuyA (length=1016) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
MTVNEMREWLRNWVANATGQSADAIDESTPMVELGLSSRDAVAMASDIED
LTGVTLTATVAFRHPTIESLATVIIEGEPEPEPYDEDEDWSRTRDVEDIA
IVGVATRFPGDLNTPDEMWEALLEGKDCVTDLPEDRWTEFLDEPRIAERV
KKARTRGGYLTDIKGFDSEFFALSKMEADNIDPQQRMALELTWEALEHAR
IPASSLRGESVGVYIGSSTNDYSFLAMSDPSIAHPYAITGTASSIIANRV
SYFYDFRGPSVAVDTACSSSLVATHQGVQALRAGEADVAIVGGVNALVTP
LVTVGFDEVGGVLAPDGRIKSFSSDADGYARSEGGGMLVLKRISDARRDG
DQILAVIAGSAVNHDGRSNGLLAPNPDAQAEVLRKAYKDAGINPRDVDYI
EAHGTGTILGDPIEADALGRIVGKGRPADKPALLGAVKSNLGHLESAAGA
ASLAKMTLALANDKLPPSINYAGPNPYIDFEKERLKVNDTVSDWPRYSGK
AIAGVSGFGFGGANAHVVMREVLAGDLVETEAAQRLLEQAREELEAKEAE
EPTKQLVPLAVSAFLTSRKRQAAAELADWIDSPEGRASSLESIGRSLSRR
NHGRSRAVVLAHDHDEAIKGLRALAEGKQHPSVLSADGPVTNGPVWVLAG
FGAQHRKMGKSLYLRNEVFAEWINKVDALIQDERGYSILELILDDNVDYT
DATCEYPIEVVQLVIFAIQIALGELLRHHGAKPAAVVGQSLGEAAASYFA
GGLSLADATRTICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIKTVFSD
YPDLEVCVYAAPTQTVIGGPPDQVDAIIARAESEGKFARKFQTKGASHTQ
QMDPLLGELAAELQGIEPKPLTTGYFSTVHEGTFIRPGSAPIHDVDYWKK
GLRHSVYFTQGIRNAVDNGHTTFLELAPNPVALMQVGLTTASAGLHDAQL
IATLARKQDEVESMISAMAQLYVHGHDLDFRTLFPRRSKGLAGALDFANI
PPTRFKRKEHWLPAHF
3D structure
PDB8cuy Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.94: 6-deoxyerythronolide-B synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNS A S38 F62 S38 F62
Gene Ontology
Molecular Function
GO:0004312 fatty acid synthase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0031177 phosphopantetheine binding
GO:0047879 erythronolide synthase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0009058 biosynthetic process
GO:0071770 DIM/DIP cell wall layer assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cuy, PDBe:8cuy, PDBj:8cuy
PDBsum8cuy
PubMed36782050
UniProtI7FMV0

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