Structure of PDB 8cti Chain A

Receptor sequence
>8ctiA (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
TLRYPVKPEEMDWSELYPEFFQVEFADIGCGYGGLLVELSPLFPDTLILG
LEIRVKVSDYVQDRIRALRAFQNIACLRSNAMKHLPNFFYKGQLTKMFFL
FPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTH
FEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQ
DP
3D structure
PDB8cti Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.33: tRNA (guanine(46)-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K111 K167 R168 K170 W173 K56 K107 R108 K110 W113
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity
GO:0160090 internal mRNA (guanine-N7-)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
GO:0033554 cellular response to stress
GO:0036265 RNA (guanine-N7)-methylation
GO:0036416 tRNA stabilization
GO:0106004 tRNA (guanine-N7)-methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0043527 tRNA methyltransferase complex
GO:0106143 tRNA (m7G46) methyltransferase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8cti, PDBe:8cti, PDBj:8cti
PDBsum8cti
PubMed36599985
UniProtQ9UBP6|TRMB_HUMAN tRNA (guanine-N(7)-)-methyltransferase (Gene Name=METTL1)

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