Structure of PDB 8ctf Chain A

Receptor sequence
>8ctfA (length=179) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
SMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYS
DFGKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIE
IGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRA
RIKTRLFTIRQEMASRSLWDSFRQSERGE
3D structure
PDB8ctf Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q3O A H41 E80 D108 E119 K134 G197 H42 E61 D89 E100 K115 G178
BS02 MN A H41 D108 E119 I120 H42 D89 E100 I101
BS03 MN A E80 D108 E61 D89
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:8ctf, PDBe:8ctf, PDBj:8ctf
PDBsum8ctf
PubMed36655124
UniProtC3W5S0

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