Structure of PDB 8cro Chain A

Receptor sequence
>8croA (length=900) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence]
KKVIGSIEFGILSPQEIRKMSAVEVTVPDTYDDDGYPIEGGVMDKRMGVI
DPGLRCETCGGRAGECPGHFGHIELARPVIHVGFAKTIYRILESTCRECG
RIKLTDEEIEEYMKKIELARNRRSEFNEIIKEIHKKAKERMVCPHCGAPQ
YPIKFEKPTIYWEIRKDEQGNEYRHRLMPTEVRDWLEKIPDKDLPLLGLD
PEKSRPEWMVLTVLPVPPVTARPSITLETGIRAEDDLTHKLVDIIRINNR
LKQNIEAGAPQLIIEDLWDLLQYHVTTYINNEAPGVPPAKHKSGRPLKTL
AQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPVEVAMELT
VPEKVTEFNIERLRKMVLNGPDKYPGANYVIDPEGRRRRIMDSNKETLAN
QLDIGWTVERHLMDGDIVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLAV
CPPYNADFDGDEMNLHVPQTEEAQAEARILMEVQNHIISPRYGGPIIGGI
QDHISGGYLLTREGAYFTRDEVEQMLMFAGVDITELPEPDKYDENGNPLW
SGKTIFSLLLPEDLTVWYRNKLCDEPERCEALEKLIEEKLMPDPEEVRKL
AYDGFVYIQNGKLLSGAIDKKAYGREDGIILDLIVREYGVERARQFLDQV
TKLTIWVITHKGFTTGIDDEDLPEEARDRIREIIREAEERVNKLIEAYKR
GELEPLPGKSLEDTLESLIMAVLAEARDNAGAVAEKYLGMDNHTVIMAKT
GARGKILNITQMAALLGQQSIRGKRLYRGFRGRVLSHFKPGDLGARAKGF
VVNSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDLK
VEYDGTVRSPEGIIVQFKYGEDGVDPMKSWRGKTVDVDRIIVRTLLKMRG
3D structure
PDB8cro Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K158 P285 K308 R313 R320 R326 Q424 T833 Y838 K157 P284 K307 R312 R319 R325 Q423 T832 Y837
BS02 rna A R423 D460 D462 R422 D459 D461
BS03 ZN A C57 C60 H70 C56 C59 H69
BS04 ZN A C97 C100 C144 C96 C99 C143
BS05 MG A D458 D460 D462 D457 D459 D461
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cro, PDBe:8cro, PDBj:8cro
PDBsum8cro
PubMed38709902
UniProtQ8U0M4

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