Structure of PDB 8crh Chain A

Receptor sequence
>8crhA (length=208) Species: 498019 (Candidozyma auris) [Search protein sequence]
GSHMMSTRPKISLIVAALQPSMGIGAKGSLPWRLKNEMKYFKDVTSKAKD
GHINAVVMGRKTWELIPERFRPLAGRLNVILSRKNDDLIDSNGVYHFSSF
DSVMKHLEKDSFRFKDMPLDKIFIIGGSQIYNLLILDSRVDNLLVTQVHF
VGEDADKPQMDTFLDWDLSKWKRLEHDKLEQYVGLDVPRGLNEEGSYNYE
YTMWEKAQ
3D structure
PDB8crh Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VIL A I9 V10 E32 F36 I61 I120 I14 V15 E37 F41 I66 I125
BS02 NDP A V10 A11 I19 G23 S24 L25 G54 R55 K56 T57 L76 S77 R78 S93 I120 G122 S123 Q124 I125 Y126 V15 A16 I24 G28 S29 L30 G59 R60 K61 T62 L81 S82 R83 S98 I125 G127 S128 Q129 I130 Y131
BS03 VIL A M33 L60 F65 M38 L65 F70
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8crh, PDBe:8crh, PDBj:8crh
PDBsum8crh
PubMed37428844
UniProtA0A0L0P1H8

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