Structure of PDB 8cr4 Chain A

Receptor sequence
>8cr4A (length=298) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
AQAGGPGGNQKIGKYNYGTDYGPLIVNDRCEMDDGNVITVDMNGSTNDSK
STPFRFACPTNTYKQINGAYSPLNDAHFFGGVVFNLYKDWFGASPLTHKL
YMKVHYGRSVENAYWDGTAVLFGDGATMFYPLVSLDVAAHEVSHGFTEQN
SGLVYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYM
DQPSRDGRSIDNAGQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEV
FVDANRYYWTATSTFNSGACGVISSAQNRNYPAADVTRAFSTVGVTCP
3D structure
PDB8cr4 Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in Escherichia coli for Structure-Based Drug Design.
ChainA
Resolution0.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.26: pseudolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H140 H144 E164 H140 H144 E164
BS02 CA A D136 E172 E175 D183 L185 D136 E172 E175 D183 L185
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0015628 protein secretion by the type II secretion system
GO:0043952 protein transport by the Sec complex
GO:0044010 single-species biofilm formation
GO:0071978 bacterial-type flagellum-dependent swarming motility
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:8cr4, PDBe:8cr4, PDBj:8cr4
PDBsum8cr4
PubMed37195753
UniProtP14756|ELAS_PSEAE Elastase (Gene Name=lasB)

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