Structure of PDB 8cp2 Chain A

Receptor sequence

>8cp2A (length=600) Species: 1424099 (Streptomyces sp. V2)

PLSVAVVGAGPRGTSVLERLCASAPELLAPGVRLTVHVVDPAPPGPGRVW
RTAQSEDLLMNTVASQVTLFTDESVNCSGPILAGPSLHEWADGAIGPDDY
PTRALYGRYLEWVFARTLRHAPPSVRVETHRARAVRLDDAADGRQHLALD
NGRTLTGLSAVVLAQGHLPVRPSAAVLRDTEHADRHALRHIPPANPADVD
LTVISPGEPVLLRGLGLNFFDHMALLTTGRGGTYVREDGVLRYVPSGREP
RVYAGSRRGLPYQARGDNAKGPYGRHLPEVLTPEAVSAFRKRADSGEAPD
FLRDIWPLVAKEVETVYYTALVRHPDFAPRYLSLPYGDPQEAELLAEFGV
DADARWDWERVSRPYAQREFAHRGEWRQWLLGYLRADAAEALRGNVDGPL
KAALDVLRDLRNELRLVVDHRGLRGDSRRDHLDRWYTPLNAFLSIGPPRR
RIEELTALLEAGVVEVLGPRLEVTREDGAWLARSPDVPGSAVRVTTLIEA
RLPEPDLGQTADALLAHLRETGQCRAHVVDGYTTGGIDVSARPYHLVDRE
GVAHPRRFAFGVPTEGVHWVTAAGARPGVDSVTLSDADAVARAVLRVAGQ

3D structure

• PDB: 8cp2 A biosynthetic aspartate N-hydroxylase performs successive oxidations by holding intermediates at a site away from the catalytic center.
• Chain: A
• Resolution: 2.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	V8 G9 G11 P12 R13 V40 D41 P42 G48 V50 W51 M61 N62 R134 A135 A165 Q166 G167 H168 L169 N196 A573 G575	V7 G8 G10 P11 R12 V39 D40 P41 G47 V49 W50 M60 N61 R133 A134 A164 Q165 G166 H167 L168 N195 A572 G574
BS02	NAP	A	L60 M61 R104 L216 G217 L218 N219 D222 S257 R258 R259 Y263 R502 L503	L59 M60 R103 L215 G216 L217 N218 D221 S256 R257 R258 Y262 R501 L502
BS03	ASP	A	R412 R416 S582	R411 R415 S581
BS04	ASP	A	S79 R593 R597	S78 R592 R596
BS05	3NP	A	Y318 W357 D358 R361 V362	Y317 W356 D357 R360 V361

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding

External links

• PDB: RCSB:8cp2, PDBe:8cp2, PDBj:8cp2
• PDBsum: 8cp2
• PubMed: 37302552
• UniProt: A0A2V1NMV1