Structure of PDB 8cp0 Chain A

Receptor sequence
>8cp0A (length=347) Species: 5855 (Plasmodium vivax) [Search protein sequence]
YKFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPDL
RNNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVSNSGDPMDDNYHGTHV
SGIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCISR
QAHMISGSFSFDEYSNIFSASVEHLRSLGILFFVSASNCAHDPDIAKCDL
AVNHRYPPILSKTHNNVIAVANLKRDLSYSLSVNSFYSNIYCQLAAPGTN
IYSTTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRNAI
VKLPSLTERVSWGGYVDILRAVNLAIDSKAAPYIKSHSWFRWKQGSR
3D structure
PDB8cp0 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.
ChainA
Resolution3.251 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.62: subtilisin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D281 D325 V383 N386 I388 I390 D5 D49 V107 N110 I112 I114
BS02 CA A E336 D344 D346 N348 V350 D353 E60 D68 D70 N72 V74 D77
BS03 CA A E336 R340 V343 D345 D352 E60 R64 V67 D69 D76
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8cp0, PDBe:8cp0, PDBj:8cp0
PDBsum8cp0
PubMed37428845
UniProtE6Y8B9

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