Structure of PDB 8coy Chain A

Receptor sequence

>8coyA (length=332) Species: 5855 (Plasmodium vivax) [Search protein sequence]

YKFNDEYRNLQWGLDLARLDETQDLINANRVSVTKICVIDSGIDYNHPDL
RNNIDVNVKELHGRKGVDDDSNGVVDDVYGANFVSNSGDPMDDNYHGTHV
SGIISAVGNNGIGIVGVDGHSKLVICKALDQHKLGRLGDMFKCIDYCISR
QAHMISGSFSFDEYSNIFSASVEHLRSLGILFFVSASNCAAKCDLAVNHR
YPPILSKTHNNVIAVANLKRDLDESYSLSVNSFYSNIYCQLAAPGTNIYS
TTPMNNYRKLNGTSMASPHVAAIASIVRSINPNLTYLQIVEILRNAIVKL
PSLTERVSWGGYVDILRAVNLAIDSKAAPYIK

3D structure

PDB

8coy 3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.

Chain

Resolution

1.507 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.4.21.62: subtilisin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Y371 H372 L405 K409 L410 G411 S434 F435 S436 N464 N546 G547 T548 S549	Y95 H96 L129 K133 L134 G135 S158 F159 S160 N188 N261 G262 T263 S264
BS02	CA	A	D281 D325 V383 N386 I388 I390	D5 D49 V107 N110 I112 I114
BS03	CA	A	E336 D344 D346 N348 V350 D353	E60 D68 D70 N72 V74 D77
BS04	CA	A	E336 R340 V343 D345 D352	E60 R64 V67 D69 D76

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8coy, PDBe:8coy, PDBj:8coy
PDBsum	8coy
PubMed	37428845
UniProt	E6Y8B9

[Back to BioLiP]