Structure of PDB 8con Chain A

Receptor sequence
>8conA (length=379) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
MSTTGQIIRCKAAVAWEAGKPLVIEEVEVAPPQKHEVRIKILFTSLCHTD
VYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECG
ECRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYHFLGTSTFS
EYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAI
FGLGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHD
KPIQQVIAEMTDGGVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSK
DDAFKTHPMNFLNERTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFIT
HTVPFSEINKAFDYMLKGESIRCIITMGA
3D structure
PDB8con Structural and biochemical characterization of Arabidopsis alcohol dehydrogenases reveals distinct functional properties but similar redox sensitivity.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C47 H69 E70 C177 C47 H69 E70 C177
BS02 ZN A C99 C102 C105 C113 C99 C102 C105 C113
BS03 NAI A H48 T181 G202 G204 V206 D226 F227 C271 T272 V295 G296 V297 F321 F322 H48 T181 G202 G204 V206 D226 F227 C271 T272 V295 G296 V297 F321 F322
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006970 response to osmotic stress
GO:0009409 response to cold
GO:0009413 response to flooding
GO:0009414 response to water deprivation
GO:0009651 response to salt stress
GO:0009737 response to abscisic acid
GO:0009744 response to sucrose
GO:0031000 response to caffeine
GO:0032355 response to estradiol
GO:0042542 response to hydrogen peroxide
GO:0071456 cellular response to hypoxia
GO:1900039 positive regulation of cellular response to hypoxia
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8con, PDBe:8con, PDBj:8con
PDBsum8con
PubMed38308388
UniProtP06525|ADH1_ARATH Alcohol dehydrogenase class-P (Gene Name=ADH1)

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