Structure of PDB 8cnj Chain A

Receptor sequence
>8cnjA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB8cnj HRas(1-166) in complex with GDP and BeF3-
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 V14 G15 K16 S17 A18 F28 V29 D30 Y32 N116 K117 D119 S145 A146 G13 V14 G15 K16 S17 A18 F28 V29 D30 Y32 N116 K117 D119 S145 A146
BS02 BEF A G12 K16 Y32 P34 T35 G60 G12 K16 Y32 P34 T35 G60
BS03 MG A S17 T35 S17 T35
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8cnj, PDBe:8cnj, PDBj:8cnj
PDBsum8cnj
PubMed38297137
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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