Structure of PDB 8cnd Chain A

Receptor sequence

>8cndA (length=534) Species: 10090 (Mus musculus)

MGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD
YFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV
YKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTDTLDPEPFVDCKEC
GRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGN
HLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMS
ESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDS
IHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDNIFHC
HPPDQKIPKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKE
LPYFEGDFWPNVLEESIKEKLYATMEKHKEVFFVIHLHAGQPPIVDPDPL
LSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVY
TCNECKHHVETRWHCTVCEDYDLCINHTHKMVKW

3D structure

• PDB: 8cnd Crystal structure of CREBBP-Y1482N histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
• Chain: A
• Resolution: 2.972 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C1199 C1200 H1291 C1294	C125 C126 H155 C158
BS02	ZN	A	C1286 C1308 C1311	C150 C172 C175
BS03	ZN	A	C1709 C1728	C505 C524
BS04	ZN	A	H1738 H1740	H527 H529
BS05	01K	A	S1432 L1434 S1436 R1443 R1446 T1447 Y1450 W1472 C1474 P1476 K1492 I1493 P1494 R1498 L1499 W1502 Y1503	S296 L298 S300 R307 R310 T311 Y314 W336 C338 P340 K356 I357 P358 R362 L363 W366 Y367
BS06	ZN	A	H1351 C1444	H215 C308

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:8cnd, PDBe:8cnd, PDBj:8cnd
• PDBsum: 8cnd
• UniProt: P45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)