Structure of PDB 8cnb Chain A

Receptor sequence

>8cnbA (length=531) Species: 10090 (Mus musculus)

MGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD
YFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV
YKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTDTLDPEPFVDCKEC
GRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGN
HLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMS
ESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDS
IHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHC
HPPDQKIPKPKRLQEWCKKMLDKAFAERIINDYKDIFKQANEDRLTSAKE
LPYFEGDFWPNVLEESIKEKLYATMEKHKEVFFVIHLHPPIVDPDPLLSC
DLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCN
ECKHHVETRWHCTVCEDYDLCINHTHKMVKW

3D structure

• PDB: 8cnb Crystal structure of CREBBP-Y1503C histone acetyltransferase domain in complex with Coenzyme A
• Chain: A
• Resolution: 1.986 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C1199 C1200 H1291 C1294	C125 C126 H155 C158
BS02	ZN	A	C1283 C1286 C1308 C1311	C147 C150 C172 C175
BS03	ZN	A	C1707 C1710 C1729	C499 C502 C521
BS04	ZN	A	C1720 H1738 H1740	C512 H524 H526
BS05	COA	A	S1436 R1446 T1447 Y1450 P1476 Y1482 K1492 I1493 P1494 R1498 L1499 W1502	S300 R310 T311 Y314 P340 Y346 K356 I357 P358 R362 L363 W366

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:8cnb, PDBe:8cnb, PDBj:8cnb
• PDBsum: 8cnb
• UniProt: P45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)