Structure of PDB 8cna Chain A

Receptor sequence

>8cnaA (length=533) Species: 10090 (Mus musculus)

MGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD
YFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV
YKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTDTLDPEPFVDCKEC
GRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGN
HLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMS
ESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDS
IHFFRPRCLCTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHC
HPPDQKIPKPKRLQEWFKKMLDKAFAERIINDYKDIFKQANEDRLTSAKE
LPYFEGDFWPNVLEESIKEKLYATMEKHKEVFFVIHLHAGQPPIVDPDPL
LSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVY
TCNECKHHVETRWHCTVCEDYDLCINHTHKMVK

3D structure

• PDB: 8cna Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
• Chain: A
• Resolution: 2.463 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C1199 C1200 H1291 C1294	C125 C126 H155 C158
BS02	ZN	A	C1283 C1286 C1308 C1311	C147 C150 C172 C175
BS03	ZN	A	C1710 C1729	C505 C524
BS04	ZN	A	C1720 H1740	C515 H529
BS05	01K	A	Y1433 L1434 S1436 T1447 Y1450 W1472 A1473 C1474 P1476 Y1482 K1492 I1493 P1494 R1498 W1502 F1503	Y297 L298 S300 T311 Y314 W336 A337 C338 P340 Y346 K356 I357 P358 R362 W366 F367

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:8cna, PDBe:8cna, PDBj:8cna
• PDBsum: 8cna
• UniProt: P45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)