Structure of PDB 8cmz Chain A

Receptor sequence

>8cmzA (length=532) Species: 10090 (Mus musculus) [Search protein sequence]

MGSSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD
YFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV
YKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTDTLDPEPFVDCKEC
GRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGN
HLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMS
ESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDS
IHFFRPRCLCTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHC
HPPDQKIPKPKRLQEWFKKMLDKAFAERIINDYKDIFKQANEDRLTSAKE
LPYFEGDFWPNVLEESIKEKLYATMEKHKEVFFVIHLHPPIVDPDPLLSC
DLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCN
ECKHHVETRWHCTVCEDYDLCINCHTHKMVKW

3D structure

PDB

8cmz Crystal structure of CREBBP-R1446C histone acetyltransferase domain in complex with Coenzyme A

Chain

Resolution

2.252 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.-
2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C1199 C1200 H1291 C1294	C125 C126 H155 C158
BS02	ZN	A	C1283 C1286 C1308 C1311	C147 C150 C172 C175
BS03	ZN	A	C1710 C1729	C502 C521
BS04	ZN	A	H1738 H1740	H525 H527
BS05	COA	A	L1434 S1436 T1447 P1476 Y1482 K1492 P1494 K1495 R1498 L1499 W1502 F1503	L298 S300 T311 P340 Y346 K356 P358 K359 R362 L363 W366 F367

Gene Ontology

	Molecular Function
GO:0004402	histone acetyltransferase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8cmz, PDBe:8cmz, PDBj:8cmz
PDBsum	8cmz
PubMed
UniProt	P45481\|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)

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