Structure of PDB 8cm7 Chain A

Receptor sequence

>8cm7A (length=956) Species: 882 (Nitratidesulfovibrio vulgaris str. Hildenborough)

ELQKLQWAKQTTSICCYCAVGCGLIVHTAKDGQGRAVNVEGDPDHPINEG
SLCPKGASIFQLGENDQRGTQPLYRAPFSDTWKPVTWDFALTEIAKRIKK
TRDASFTEKNAAGDLVNRTEAIASFGSAAMDNEECWAYGNILRSLGLVYI
EHQARICHSPTVPALAESFGRGAMTNHWNDLANSDCILIMGSNAAENHPI
AFKWVLRAKDKGATLIHVDPRFTRTSARCDVYAPIRSGADIPFLGGLIKY
ILDNKLYFTDYVREYTNASLIVGEKFSFKDGLFSGYDAANKKYDKSMWAF
ELDANGVPKRDPALKHPRCVINLLKKHYERYNLDKVAAITGTSKEQLQQV
YKAYAATGKPDKAGTIMYAAGWTQHSVGVQNIRAMAMIQLLLGNIGVAGG
GVNALRGESNVQGSTDQGLLAHIWPGYNPVPNSKAATLELYNAATPQSKD
PMSVNWWQNRPKYVASYLKALYPDEEPAAAYDYLPRIDAGRKLTDYFWLN
IFEKMDKGEFKGLFAWGMNPACGGANANKNRKAMGKLEWLVNVNLFENET
SSFWKGPGMNPAEIGTEVFFLPCCVSIEKEGSVANSGRWMQWRYRGPKPY
AETKPDGDIMLDMFKKVRELYAKEGGAYPAPIAKLNIADWEEHNEFSPTK
VAKLMNGYFLKDTEVGGKQFKKGQQVPSFAFLTADGSTCSGNWLHAGSFT
DAGNLMARRDKTQTPEQARIGLFPNWSFCWPVNRRILYNRASVDKTGKPW
NPAKAVIEWKDGKWVGDVVDGGGDPGTKHPFIMQTHGFGALYGPGREEGP
FPEHYEPLECPVSKNPFSKQLHNPVKAVCDPRYPFIGTTYRVTEHWQTGL
MTRRCAWLVEAEPQIFCEISKELAKLRGIGNGDTVKVSSLRGALEAVAIV
TERIRPFKIEGVDVHMVGLPWHYGWMVPKNGGDTANLLTPSAIPETKAFM
VDVRKV

3D structure

• PDB: 8cm7 W-formate dehydrogenase C872A from Desulfovibrio vulgaris - with Formamide
• Chain: A
• Resolution: 2.117 Å

Enzymatic activity

• Enzyme Commision number: 1.2.1.2: Transferred entry: 1.17.1.9.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MGD	A	K90 G226 S227 N228 N232 D254 P255 R256 S272 D275 A404 A405 G406 H410 G442 Y883 R884 V885 T886 H888 W889 Q890 K996	K55 G191 S192 N193 N197 D219 P220 R221 S237 D240 A369 A370 G371 H375 G407 Y840 R841 V842 T843 H845 W846 Q847 K947
BS02	MGD	A	A164 Q188 I191 U192 Q409 E443 G552 M553 N554 G558 N579 L580 C608 D641 T882 R884 Q890 T891 L893 M894 W964 N979 T995	A129 Q153 I156 U157 Q374 E408 G517 M518 N519 G523 N544 L545 C573 D606 T839 R841 Q847 T848 L850 M851 W921 N936 T946
BS03	SF4	A	C50 C53 C57 C88 K90 G91 I235	C15 C18 C22 C53 K55 G56 I200

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008863 formate dehydrogenase (NAD+) activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0030151 molybdenum ion binding
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0047111 formate dehydrogenase (cytochrome-c-553) activity
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0009061 anaerobic respiration
• GO:0045333 cellular respiration

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:8cm7, PDBe:8cm7, PDBj:8cm7
• PDBsum: 8cm7
• PubMed: 37985883
• UniProt: Q72EJ1