Structure of PDB 8ckq Chain A

Receptor sequence

>8ckqA (length=456) Species: 4577 (Zea mays)

GGRLSVDASDIAEASRDFGGVARAEPMAVFHPRAAGDVAGLVGAAFRSAR
GFRVSARGHGHSISGQAQAAGGVVVDMSRVARALPVHSAALGGHYVDVWG
GELWVDVLNWTLSHGGLAPRSWTDYLYLSVGGTLSNAGISGQAFHHGPQI
SNVYELDVVTGKGEVVTCSETENPDLFFGVLGGLGQFGIITRARIALERA
PKRVRWIRALYSNFSEFTADQERLISLGSGGGRRFDYVEGFVVAAEGSVL
YCLEVTKNYDDETAGSVDQDVDTLLGELNFLPGTVFTTDLPYVDFLDRVH
KAELKLRAKGMWEVPHPWLNLFVPASRIADFDRGVFRGVLGGAGAGGPVL
IYPMNKHKWDPRSSAVTPDEEVFYLVAFLRSALPGAPESLEALARQNQRI
LDFCAGTGIGAKQYLPGHKARHEWAEHFGAARWDRFARLKAEFDPRAILA
AGQGIF

3D structure

• PDB: 8ckq Cytokinin oxidase/dehydrogenase inhibitors: progress toward a practice
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 1.5.99.12: cytokinin dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	F57 A95 R96 G97 H98 G99 H100 S101 Q105 A106 T169 D170 Y171 L174 S175 G177 G178 S181 N182 G184 I185 I235 I236 Y487	F18 A56 R57 G58 H59 G60 H61 S62 Q66 A67 T123 D124 Y125 L128 S129 G131 G132 S135 N136 G138 I139 I189 I190 Y414
BS02	UZX	A	D170 I185 V370 W389 N391 L448 L452 Y487	D124 I139 V299 W318 N320 L375 L379 Y414

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0016491 oxidoreductase activity
• GO:0019139 cytokinin dehydrogenase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0071949 FAD binding

Biological Process

• GO:0009690 cytokinin metabolic process

External links

• PDB: RCSB:8ckq, PDBe:8ckq, PDBj:8ckq
• PDBsum: 8ckq
• PubMed: 38776394
• UniProt: E3T1W8