Structure of PDB 8cko Chain A

Receptor sequence

>8ckoA (length=492) Species: 176299 (Agrobacterium fabrum str. C58)

QERRALRLGVNGLPNSLEPVNAISNVGPRIVNQIFDTLIARDFFAKGAPG
NAIDLVPALAESWERIDEKSVRFKLRQKVMFHDGVELTADDVAYTFSSER
LWGPEAIKKIPLGKSYSLDFDEPVVEDKYTVTLRTKTPSYLIETFVASWM
SRIVPKEYYKKLGAVDFGNKPVGTGPYKFVEFVAGDRVVLEANDAYWGPK
PTASKITYQIVAEPATRVAGLISGEYDIITTLTPDDIQLINSYPDLETRG
TLIENFHMFTFNMNQEVFKDKKLRRALALAVNRPIMVEALWKKQASIPAG
FNFPNYGETFDPKRKAMEYNVEEAKRLVKESGYDGTPITYHTMGNYYANA
MPALMMMIEMWKQIGVNVVMKTYAPGSFPPDNQTWMRNWSNGQWMTDAYA
TIVPEFGPNGQVQKRWGWKAPAEFNELCQKVTVLPNGKERFDAYNRMRDI
FEEEAPAVILYQPYDVYAARKDVHWKPVSFEMMEFRNNLSFG

3D structure

• PDB: 8cko A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity.
• Chain: A
• Resolution: 1.421 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	Y376 Y402 F407	Y347 Y373 F378
BS02	GLC	A	Y376 Y402 F407	Y347 Y373 F378
BS03	BNX	A	S53 N54 Y145 W178 Y375 Y376 S419 N420 G421 T430 E434 E510	S24 N25 Y116 W149 Y346 Y347 S390 N391 G392 T401 E405 E481
BS04	ALX	A	S53 N54 Y145 W178 Y375 Y376 S419 N420 G421 T430 E434 E510	S24 N25 Y116 W149 Y346 Y347 S390 N391 G392 T401 E405 E481

Gene Ontology

Molecular Function

• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:8cko, PDBe:8cko, PDBj:8cko
• PDBsum: 8cko
• PubMed: 38058289
• UniProt: Q52012