Structure of PDB 8cke Chain A

Receptor sequence

>8ckeA (length=491) Species: 176299 (Agrobacterium fabrum str. C58)

ERRALRLGVNGLPNSLEPVNAISNVGPRIVNQIFDTLIARDFFAKGAPGN
AIDLVPALAESWERIDEKSVRFKLRQKVMFHDGVELTADDVAYTFSSERL
WGPEAIKKIPLGKSYSLDFDEPVVEDKYTVTLRTKTPSYLIETFVASWMS
RIVPKEYYKKLGAVDFGNKPVGTGPYKFVEFVAGDRVVLEANDAYWGPKP
TASKITYQIVAEPATRVAGLISGEYDIITTLTPDDIQLINSYPDLETRGT
LIENFHMFTFNMNQEVFKDKKLRRALALAVNRPIMVEALWKKQASIPAGF
NFPNYGETFDPKRKAMEYNVEEAKRLVKESGYDGTPITYHTMGNYYANAM
PALMMMIEMWKQIGVNVVMKTYAPGSFPPDNQTWMRNWSNGQWMTDAYAT
IVPEFGPNGQVQKRWGWKAPAEFNELCQKVTVLPNGKERFDAYNRMRDIF
EEEAPAVILYQPYDVYAARKDVHWKPVSFEMMEFRNNLSFG

3D structure

• PDB: 8cke A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity.
• Chain: A
• Resolution: 1.298 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	L42 P43 S53 M372	L12 P13 S23 M342
BS02	FRU	A	Y375 Y376 Y402 F407	Y345 Y346 Y372 F377
BS03	GLC	A	L42 P43 S53 M372	L12 P13 S23 M342
BS04	FRU	A	Y375 Y376 Y402 F407 W418	Y345 Y346 Y372 F377 W388
BS05	VDF	A	S53 N54 W178 Y375 Y376 W418 S419 N420 G421 E434 E510	S23 N24 W148 Y345 Y346 W388 S389 N390 G391 E404 E480
BS06	LAO	A	S53 N54 W178 Y375 Y376 W418 S419 N420 G421 E434 E510	S23 N24 W148 Y345 Y346 W388 S389 N390 G391 E404 E480

Gene Ontology

Molecular Function

• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:8cke, PDBe:8cke, PDBj:8cke
• PDBsum: 8cke
• PubMed: 38058289
• UniProt: Q52012