Structure of PDB 8ck8 Chain A

Receptor sequence
>8ck8A (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
EFKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHAL
DSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPPQCIM
CVNYVLSEIE
3D structure
PDB8ck8 Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors.
ChainA
Resolution2.302 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UYF A H248 M252 A277 Y281 H293 Y307 M309 T321 G323 I337 C339 N341 H14 M18 A43 Y47 H59 Y73 M75 T87 G89 I99 C101 N103
External links
PDB RCSB:8ck8, PDBe:8ck8, PDBj:8ck8
PDBsum8ck8
PubMed37403966
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

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