Structure of PDB 8ck4 Chain A

Receptor sequence
>8ck4A (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
EFKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHAL
DSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPQCIMC
VNYVLSEIE
3D structure
PDB8ck4 Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors.
ChainA
Resolution2.29 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UY3 A H248 M252 F254 A277 Y281 H293 S304 Y307 M309 T321 I337 C339 N341 H14 M18 F20 A43 Y47 H59 S70 Y73 M75 T87 I98 C100 N102
External links
PDB RCSB:8ck4, PDBe:8ck4, PDBj:8ck4
PDBsum8ck4
PubMed37403966
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

[Back to BioLiP]