Structure of PDB 8ck3 Chain A

Receptor sequence
>8ck3A (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
EFKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHAL
DSENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPQPQCI
MCVNYVLSEIEK
3D structure
PDB8ck3 Discovery of Cycloalkyl[ c ]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2 alpha Inhibitors.
ChainA
Resolution1.707 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UXU A S246 H248 M252 F254 Y281 H293 Y307 M309 T321 C339 N341 S12 H14 M18 F20 Y47 H59 Y73 M75 T87 C102 N104
External links
PDB RCSB:8ck3, PDBe:8ck3, PDBj:8ck3
PDBsum8ck3
PubMed37403966
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

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