Structure of PDB 8cjo Chain A

Receptor sequence
>8cjoA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPWFPKKISDLDHCANRVLMYGDADHPGFKDNVYRKRRKYFADLAMNYK
HGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGY
REDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYV
RHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQ
KLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDP
KITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIK
3D structure
PDB8cjo Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
ChainA
Resolution1.86634 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.16.4: tryptophan 5-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H272 H277 E317 H166 H171 E211
BS02 UWL A L236 P238 F241 H272 Y312 F313 E317 I366 L130 P132 F135 H166 Y206 F207 E211 I260
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0009072 aromatic amino acid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8cjo, PDBe:8cjo, PDBj:8cjo
PDBsum8cjo
PubMed37905925
UniProtP17752|TPH1_HUMAN Tryptophan 5-hydroxylase 1 (Gene Name=TPH1)

[Back to BioLiP]