Structure of PDB 8cjm Chain A

Receptor sequence
>8cjmA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPWFPKKISDLDHCANRVLGFKDNVYRKRRKYFADLAMNYKHGDPIPKV
EFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQL
EDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFY
TPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFF
TVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQEC
LITTFQDVYFVSESFEDAKEKMREFTKTI
3D structure
PDB8cjm Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.16.4: tryptophan 5-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H272 H277 E317 H158 H163 E203
BS02 UXL A Y235 L236 P238 F241 T253 P268 H272 E317 Y121 L122 P124 F127 T139 P154 H158 E203
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0009072 aromatic amino acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8cjm, PDBe:8cjm, PDBj:8cjm
PDBsum8cjm
PubMed37905925
UniProtP17752|TPH1_HUMAN Tryptophan 5-hydroxylase 1 (Gene Name=TPH1)

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