Structure of PDB 8cj9 Chain A

Receptor sequence

>8cj9A (length=494) Species: 4577 (Zea mays)

GLPGDLFGLGIASRIRTDSNSTAKAATDFGQMVRAAPEAVFHPATPADIA
ALVRFSATSAAPFPVAPRGQGHSWRGQALAPGGVVVDMGSLGRGPRINVS
AAAEPFVDAGGEQLWVDVLRATLRHGLAPRVWTDYLRLTVGGTLSNAGIG
GQAFRHGPQIANVHELDVVTGTGEMVTCSMDVNSDLFMAALGGLGQFGVI
TRARIRLEPAPKRVRWVRLAYTDVATFTKDQEFLISNRTQVGFDYVEGQV
QLNRSLVEGPKSTPFFSGADLARLAGLASRTGPTAIYYIEGAMYYTEDTA
ISVDKKMKALLDQLSFEPGFPFTKDVTFVQFLDRVREEERVLRSAGAWEV
PHPWLNLFVPRSRILDFDDGVFKALLKDANPAGIILMYPMNKDRWDDRMT
AMTPATDDDDNVFYAVSFLWSALSADDVPQLERWNKAVLDFCDRSGIECK
QYLPHYTSQDGWRRHFGAKWSRIAELKARYDPRALLSPGQRIFP

3D structure

• PDB: 8cj9 Cytokinin oxidase/dehydrogenase inhibitors: progress toward a practice
• Chain: A
• Resolution: 1.93 Å

Enzymatic activity

• Enzyme Commision number: 1.5.99.12: cytokinin dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	F60 P98 G100 Q101 G102 H103 S104 Q108 T166 D167 Y168 L171 T172 G175 S178 N179 G181 I182 G228 V232 I233 W388 Y486 L487	F29 P67 G69 Q70 G71 H72 S73 Q77 T133 D134 Y135 L138 T139 G142 S145 N146 G148 I149 G195 V199 I200 W354 Y452 L453
BS02	UZX	A	W105 D167 I182 V369 E372 W388 I418 L420 L453 L487	W74 D134 I149 V335 E338 W354 I384 L386 L419 L453

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0016491 oxidoreductase activity
• GO:0019139 cytokinin dehydrogenase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0071949 FAD binding

Biological Process

• GO:0009690 cytokinin metabolic process

External links

• PDB: RCSB:8cj9, PDBe:8cj9, PDBj:8cj9
• PDBsum: 8cj9
• PubMed: 38776394
• UniProt: E3T1X2