Structure of PDB 8ciy Chain A

Receptor sequence
>8ciyA (length=356) Species: 562 (Escherichia coli) [Search protein sequence]
GRMKFTVEREHLLKPLQQVSGTLPILGNLLLQVADGTLSLTGTDLEMEMV
ARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRS
RFSLSTLPAADFPNLWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLN
GMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRM
LDPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLEAGC
DLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILDVTY
SGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSAAYV
VMPMRL
3D structure
PDB8ciy Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R152 Y154 G174 H175 R176 R240 M362 P363 R365 R146 Y148 G168 H169 R170 R230 M352 P353 R355
BS02 CA A E6 G85 E8 G81
BS03 MG A R205 D208 R199 D202
BS04 MG A R240 D243 R230 D233
BS05 MG A S346 M362 S336 M352
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032297 negative regulation of DNA-templated DNA replication initiation
GO:0042276 error-prone translesion synthesis
GO:0044787 bacterial-type DNA replication
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009360 DNA polymerase III complex
GO:0030894 replisome
GO:1990078 replication inhibiting complex
GO:1990085 Hda-beta clamp complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ciy, PDBe:8ciy, PDBj:8ciy
PDBsum8ciy
PubMed38278788
UniProtP0A988|DPO3B_ECOLI Beta sliding clamp (Gene Name=dnaN)

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