Structure of PDB 8cix Chain A

Receptor sequence
>8cixA (length=360) Species: 562 (Escherichia coli) [Search protein sequence]
GRMKFTVEREHLLKPLQQVSGPLTLPILGNLLLQVADGTLSLTGTDLEME
MVARVALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSG
RSRFSLSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVR
YYLNGMLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIE
LMRMLDPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHL
EAGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEIL
DVTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQS
AAYVVMPMRL
3D structure
PDB8cix Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G174 H175 R176 M362 P363 M364 G172 H173 R174 M356 P357 M358
BS02 CA A E6 G85 E8 G83
BS03 CA A P242 D243 P236 D237
BS04 MG A M1 G66 A67 M3 G64 A65
BS05 MG A N32 S109 T110 N30 S107 T108
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032297 negative regulation of DNA-templated DNA replication initiation
GO:0042276 error-prone translesion synthesis
GO:0044787 bacterial-type DNA replication
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009360 DNA polymerase III complex
GO:0030894 replisome
GO:1990078 replication inhibiting complex
GO:1990085 Hda-beta clamp complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cix, PDBe:8cix, PDBj:8cix
PDBsum8cix
PubMed38278788
UniProtP0A988|DPO3B_ECOLI Beta sliding clamp (Gene Name=dnaN)

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