Structure of PDB 8cip Chain A

Receptor sequence

>8cipA (length=665) Species: 1422 (Geobacillus stearothermophilus)

SIEELAITTIRTLSIDAIEKAKSGHPGMPMGAAPMAYTLWTKFMNHNPAN
PNWFNRDRFVLSAGHGSMLLYSLLHLSGYDVSMDDLKQFRQWGSKTPGHP
EYGHTPGVEATTGPLGQGIAMAVGMAMAERHLAATYNRDGFEIINHYTYA
ICGDGDLMEGVASEAASLAGHLKLGRLIVLYDSNDISLDGELNLSFSENV
AQRFQAYGWQYLRVEDGNNIEEIAKALEEARADLSRPTLIEVKTTIGYGA
PNKAGTSGVHGAPLGAQEAKLTKEAYRWTFAEDFYVPEEVYAHFRATVQE
PGAKKEAKWNEQLAAYEQAHPELAAQLKRAIEGKLPDGWEASLPVYEAGK
SLATRSSSGEVINAIAKAVPQLFGGSADLASSNKTLIKGGGNFFPGSYEG
RNVWFGVREFAMGAALNGMALHGGLKVFGGTFFVFSDYLRPAIRLAALMG
LPVIYVLTHDSIAVGEDGPTHEPIEQLASLRAMPNLSVIRPADANETAAA
WRLALESTDKPTALVLTRQDVPTLAATAELAYEGVKKGAYVVSPAKNGAP
EALLLATGSEVGLAVKAQEALAAEGIHVSVISMPSWDRFEAQPKSYRDEV
LPPAVTKRLAIEMGASLGWERYVGAEGDILAIDRFGASAPGEKIMAEYGF
TVDNVVRRTKALLGK

3D structure

• PDB: 8cip Thermostable Transketolase from Geobacillus stearothermophilus: Characterization and Catalytic Properties
• Chain: A
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 2.2.1.1: transketolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPP	A	H68 L118 D157 G158 N187 I189 H263	H65 L115 D154 G155 N184 I186 H260
BS02	MG	A	D157 N187 I189	D154 N184 I186
BS03	TPP	A	D381 E412 F438 Y441	D378 E409 F435 Y438

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004802 transketolase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006098 pentose-phosphate shunt

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:8cip, PDBe:8cip, PDBj:8cip
• PDBsum: 8cip
• UniProt: A0A0I9QGZ2|TKT_GEOSE Transketolase (Gene Name=tkt)