Structure of PDB 8chs Chain A

Receptor sequence
>8chsA (length=718) Species: 9606 (Homo sapiens) [Search protein sequence]
DPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPPTLTDKGRGRFALI
IYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFCSINPKSPLLYVTRPS
TYEPVLLHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKR
LSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIPNFTFN
LGYSGKFFHTGTNAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVL
AEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRV
TSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSEL
DKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTN
LRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFP
KLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGI
DWYMEFFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVLTILIN
PADRAYSWYQHQRAHDDPVALKYTFHEVITAGSDASSKLRALQNRCLVPG
WYATHIERWLSAYHANQILVLDGKLLRTEPAKVMDMVQKFLGVTNTIDYH
KTLAFDPKKGFWCCLGKSKGRKYPEMDLDSRAFLKDYYRDHNIELSKLLY
KMGQTLPTWLREDLQNTR
3D structure
PDB8chs Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1
ChainA
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.2.8: [heparan sulfate]-glucosamine N-sulfotransferase.
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3P A K614 T615 G616 T617 T618 A619 S712 G778 L781 R782 F816 K833 G834 Y837 K459 T460 G461 T462 T463 A464 S557 G623 L626 R627 F661 K669 G670 Y673
BS02 CA A D320 H393 H529 D165 H238 H374
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008146 sulfotransferase activity
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0019213 deacetylase activity
GO:0050119 N-acetylglucosamine deacetylase activity
GO:0102140 heparan sulfate N-deacetylase activity
Biological Process
GO:0000271 polysaccharide biosynthetic process
GO:0003279 cardiac septum development
GO:0006954 inflammatory response
GO:0007507 heart development
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0008283 cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO:0030203 glycosaminoglycan metabolic process
GO:0030210 heparin biosynthetic process
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0035904 aorta development
GO:0043410 positive regulation of MAPK cascade
GO:0045880 positive regulation of smoothened signaling pathway
GO:0048702 embryonic neurocranium morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0060976 coronary vasculature development
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0032588 trans-Golgi network membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8chs, PDBe:8chs, PDBj:8chs
PDBsum8chs
PubMed38351061
UniProtP52848|NDST1_HUMAN Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (Gene Name=NDST1)

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