Structure of PDB 8ch1 Chain A

Receptor sequence

>8ch1A (length=478) Species: 311402 (Allorhizobium ampelinum S4)

ERRALKIGVNGIPVTLEPINAISNVGPRIVNQIFDTLVVRDFFSNGAPGN
GINLMPSLAESWERIDDKSVRFKLRQKVMFHDGVEMTADDVAYTFSSERL
WGPDAIKVIPLGGSYALDFDEPVVEDKYTVVIRTKTPTPLTESYMASWMG
RIVPKAYYKTLGTAAFGNKPVGTGPYKFVEFVANDRVVIEANDAYWGLKP
TASKITYQLVAEPATRVAGLISGEYDIVTTLTPDDMALINSYPDLETRGN
IVENFHMFTFNMNQPVFQSKPLRRALALAVNRPLIVQSLWMNKATIPNGF
NFPNYGKTFDPNRRAMEYNIEEAKRLVKESGYDGTPITYHTMGNYYANAV
PALMMMIEMWKQIGVTVVPKVYAPGGAPKDQDSYMRNWSNGQWMTDAWAT
MICEFGPKGQVQKRWGWKAPAEFNDLCTKVSQIPDSKERFDAFNRLRDIF
EEEAPAVILYQPFDVYAARKDVHWRPIS

3D structure

• PDB: 8ch1 A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity.
• Chain: A
• Resolution: 1.496 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	I42 P43 V44 S53 M372	I12 P13 V14 S23 M342
BS02	GLC	A	I42 P43 V44 S53 M372	I12 P13 V14 S23 M342
BS03	FRU	A	Y376 W418	Y346 W388
BS04	VDF	A	S53 N54 Y145 W178 Y375 Y376 W418 S419 N420 G421 E434	S23 N24 Y115 W148 Y345 Y346 W388 S389 N390 G391 E404
BS05	LAO	A	S53 N54 Y145 W178 Y375 Y376 W418 S419 N420 G421 E434	S23 N24 Y115 W148 Y345 Y346 W388 S389 N390 G391 E404

Gene Ontology

Molecular Function

• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:8ch1, PDBe:8ch1, PDBj:8ch1
• PDBsum: 8ch1
• PubMed: 38058289
• UniProt: B9JXG4