Structure of PDB 8cgp Chain A

Receptor sequence
>8cgpA (length=857) Species: 9606 (Homo sapiens) [Search protein sequence]
GKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNI
ILHSTGHNISRVTFMSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLK
IEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPA
FKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVA
FIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEI
QYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTK
IIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYED
FLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLK
TYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTW
TLQKGFPLVTVQKKGKELFIQQERFFLNSYLWHIPLSYVTEGRNYSKYQS
VSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINP
YVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALF
QTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELR
SALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKT
DKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFR
TQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGS
TYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKS
LTWWLRT
3D structure
PDB8cgp Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase.
ChainA
Resolution2.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H464 H468 E487 H304 H308 E327
BS02 UKG A K460 I461 H464 E494 Y495 F544 D545 Y549 Y961 K300 I301 H304 E334 Y335 F384 D385 Y389 Y791
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8cgp, PDBe:8cgp, PDBj:8cgp
PDBsum8cgp
PubMed38244767
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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