Structure of PDB 8cdq Chain A

Receptor sequence

>8cdqA (length=814) Species: 36329 (Plasmodium falciparum 3D7)

AVTNEEIKTASKIVRRVSNVEAFDKSGSVFKGYQIWTDISPTIENDPNIM
FVKCVVQQGSKKEKLTVVQIDPPGTGTPYDIDPTHAWNCNSQVDPMSFGD
IGLLNHTNIPCVLDFLKHRYLKNQIYTTAVPLIVAINPYKDLGNTTNEWI
RRYRDTADHTKLPPHVFTCAREALSNLHGVNKSQTIIVSGESGAGKTEAT
KQIMRYFASSKSGNMDLRIQTAIMAANPVLEAFGNAKTIRNNNSSRFGRF
MQLVISHEGGIRYGSVVAFLLEKSRIITQDDNERSYHIFYQFLKGANSTM
KSKFGLKGVTEYKLLNPNSTEVSGVDDVKDFEEVIESLKNMELSESDIEV
IFSIVAGILTLGNVRLIEKQESDAAAIMDEDMGVFNKACELMYLDPELIK
REILIKVTVAGGTKIEGRWNKNDAEVLKSSLCKAMYEKLFLWIIRHLNSR
IEPEGGFKTFMGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFER
ESKLYKDEGISTAELKYTSNKEVINVLCEKGKSVLSYLEDQCLAPGGTDE
KFVSSCATNLKENNKFTPAKVASNKNFIIQHTIGPIQYCAESFLLKNKDV
LRGDLVEVIKDSPNPIVQQLFEGQVIEKGKIAKGSLIGSQFLNQLTSLMN
LINSTEPHFIRCIKPNENKKPLEWCEPKILIQLHALSILEALVLRQLGYS
YRRTFEEFLYQYKFVDIAAAEDSSVENQNKCVNILKLSGLSESMYKIGKS
MVFLKQEGAKILTKIQREKLVEWENCVSVIEAAILKHKYKQKVNKNIPSL
LRVQAHIRKKMVAQ

3D structure

• PDB: 8cdq Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.
• Chain: A
• Resolution: 2.21 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AGS	A	N138 P139 K141 S193 G194 A195 G196 K197 T198 E199 N242 S245 S246 F471	N137 P138 K140 S192 G193 A194 G195 K196 T197 E198 N241 S244 S245 F467
BS02	MG	A	T198 S246	T197 S245
BS03	KQ0	A	R247 F248 G249 L271 E273 I470 F471 E482 F485 T489	R246 F247 G248 L270 E272 I466 F467 E478 F481 T485

Gene Ontology

Molecular Function

• GO:0000146 microfilament motor activity
• GO:0003774 cytoskeletal motor activity
• GO:0003779 actin binding
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0051015 actin filament binding

Biological Process

• GO:0007015 actin filament organization

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0015629 actin cytoskeleton
• GO:0016020 membrane
• GO:0016459 myosin complex
• GO:0020039 pellicle
• GO:0070258 inner membrane pellicle complex
• GO:0160055 glideosome

External links

• PDB: RCSB:8cdq, PDBe:8cdq, PDBj:8cdq
• PDBsum: 8cdq
• PubMed: 37308472
• UniProt: Q8IDR3|MYOA_PLAF7 Myosin-A (Gene Name=MyoA)