Structure of PDB 8cdo Chain A

Receptor sequence

>8cdoA (length=478) Species: 358 (Agrobacterium tumefaciens)

DRRALRIGVNGLPPSLEPINGISNTGPRIINQIFDALIRRDYFADGAKGN
NIKLVPALAESFERIDDKSIRFKLRQGVKFHNGAEMTAEDVAFTFSSERL
WGDEAIKTVPNGRNYSPNWDEPVVEDKYTVVLRTKTPSYLIEKYLGSWLG
PIVPKEYYKSLGAVAFGNKPIGTGPYKFRELVANDHVTLEANDGYWGDKP
TASTITYQVVAEPATRVAGLISGEYDIITTLTPDDMALVDGYSDLETRGT
LIENLHMFTFNMNQPIFQNKTLRRALALAVNRPLIVEALWKNKASIPNGF
NFEFNLKEAKRLVKESGYDGTPITYHTMGNYYANAVPALMMMIEMWKAAG
ITVVPKIFAPGTTPKDSDILIRNWSNGQWLTDGLTTMVSEFGPGRQVQKR
WGWKAPAEFNNLCDQVAQLKDGEERSAAFNRLRDIFEDEAPAVLMYQPYD
VYAARKDVQWSPVSFETMEFRGNLNFKH

3D structure

• PDB: 8cdo A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity.
• Chain: A
• Resolution: 1.32 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	P44 M372 T406 T407	P14 M328 T362 T363
BS02	FRU	A	Y375 Y376 R416	Y331 Y332 R372
BS03	GLC	A	P44 M372 T406 T407	P14 M328 T362 T363
BS04	FRU	A	Y375 Y376 R416	Y331 Y332 R372
BS05	BNX	A	N54 Y375 Y376 S419 N420 G421 E434 E510	N24 Y331 Y332 S375 N376 G377 E390 E466
BS06	ALX	A	S53 N54 W178 Y375 Y376 S419 N420 E434 E510	S23 N24 W148 Y331 Y332 S375 N376 E390 E466

Gene Ontology

Molecular Function

• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:8cdo, PDBe:8cdo, PDBj:8cdo
• PDBsum: 8cdo
• PubMed: 38058289
• UniProt: A5WYD2