Structure of PDB 8cdn Chain A

Receptor sequence
>8cdnA (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
ELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSF
LLDFVAADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAP
VSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPET
QFIAVTAYQNEEITALKIKYNPFAKAFLDAK
3D structure
PDB8cdn Crystal structure of human Brachyury in complex with a single T box binding element DNA
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R69 R70 K147 Y198 T204 I208 N211 F213 F217 R29 R30 K107 Y158 T164 I168 N171 F173 F177
BS02 dna A K103 N150 S162 T196 A216 K63 N110 S122 T156 A176
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cdn, PDBe:8cdn, PDBj:8cdn
PDBsum8cdn
PubMed
UniProtO15178|TBXT_HUMAN T-box transcription factor T (Gene Name=TBXT)

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