Structure of PDB 8cc4 Chain A

Receptor sequence
>8cc4A (length=298) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
AEAGGPGGNQKIGKYTYGSDYGPLIVNDRCEMDDGNVITVDMNSSTDDSK
TTPFRFACPTNTYKQVNGAYSPLNDAHFFGGVVFKLYRDWFGTSPLTHKL
YMKVHYGRSVENAYWDGTAMLFGDGATMFYPLVSLDVAAHEVSHGFTEQN
SGLIYRGQSGGMNEAFSDMAGEAAEFYMRGKNDFLIGYDIKKGSGALRYM
DQPSRDGRSIDNASQYYNGIDVHHSSGVYNRAFYLLANSPGWDTRKAFEV
FVDANRYYWTATSNYNSGACGVIRSAQNRNYSAADVTRAFSTVGVTCP
3D structure
PDB8cc4 Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.26: pseudolysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D136 E172 E175 L185 D136 E172 E175 L185
BS02 U7F A N112 M128 F129 H140 E141 E164 L197 R198 H223 N112 M128 F129 H140 E141 E164 L197 R198 H223
BS03 ZN A H140 H144 E164 H140 H144 E164
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8cc4, PDBe:8cc4, PDBj:8cc4
PDBsum8cc4
PubMed38161367
UniProtP14756|ELAS_PSEAE Elastase (Gene Name=lasB)

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