Structure of PDB 8cb0 Chain A

Receptor sequence
>8cb0A (length=256) Species: 142864 (Cylindrospermum stagnale) [Search protein sequence]
GSEPTFVVNASLLPSKVLGLQVQRPQSFNYQPGDYLFIKCPGISKFEWHP
FTISSAPEMPDVLTLHIRAVGSWTGKLYQLIREQREEWIRSGSSQSLPGV
PVYIDGPYGTPSTHIFESKYAILICAGIGVTPFASILKSILHRNQQNPAK
MPLKKVHFYWLNREQKAFEWFVELLSKIEAEDTNNLFDLNLYLTLITGLK
SRTKTGRPDWEEIFKDVAKQHAPDNVEVFFCGPTGLALQLRHLCTKYGFG
YRKENF
3D structure
PDB8cb0 Targeting ROS through the discovery of isoform-selective NADPH oxidase inhibitors
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A Y445 H459 P460 F461 T462 H476 I477 V480 G481 S482 W483 T484 I538 T541 Y35 H49 P50 F51 T52 H66 I67 V70 G71 S72 W73 T74 I128 T131
BS02 U4F A C668 E691 C231 E254
BS03 NAP A A536 I538 G539 N572 R573 T604 G669 P670 L673 N692 A126 I128 G129 N162 R163 T194 G232 P233 L236 N255
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8cb0, PDBe:8cb0, PDBj:8cb0
PDBsum8cb0
PubMed37884805
UniProtK9WT99

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