Structure of PDB 8cap Chain A

Receptor sequence
>8capA (length=247) Species: 142864 (Cylindrospermum stagnale) [Search protein sequence]
EPTFVVNASLLPSKVLGLQVQRPQSFNYQPGDYLFIKCPGISKFEWHPFT
ISSAPEMPDVLTLHIRAVGSWTGKLYQLIREQREEWIRSGSSQSLPGVPV
YIDGPYGTPSTHIFESKYAILICAGIGVTPFASILKSILHRNQQNPAKMP
LKKVHFYWLNREQKAFEWFVELLSKIEAEDTNNLFDLNLYLTSRTKTGRP
DWEEIFKDVAKQHAPDNVEVFFCGPTGLALQLRHLCTKYGFGYRKEN
3D structure
PDB8cap Targeting ROS through the discovery of isoform-selective NADPH oxidase inhibitors
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 FAD A H459 P460 F461 T462 I477 R478 G481 S482 W483 T484 T541 H47 P48 F49 T50 I65 R66 G69 S70 W71 T72 T129
BS02 U4O A V427 T462 H476 R478 I538 T541 F578 V15 T50 H64 R66 I126 T129 F166
BS03 FAD A L675 R678 L230 R233
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function

View graph for
Cellular Component
External links
PDB RCSB:8cap, PDBe:8cap, PDBj:8cap
PDBsum8cap
PubMed37884805
UniProtK9WT99

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