Structure of PDB 8caa Chain A

Receptor sequence
>8caaA (length=205) Species: 9606 (Homo sapiens) [Search protein sequence]
RSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGDPYLEAVDIRQIYDK
FPEKKGGLKDLFERGPSNAFFLVKFWADLNTNSSFYGVSSQYESPENMII
TCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLK
HLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHI
YRLVK
3D structure
PDB8caa Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.
ChainA
Resolution1.999 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U3F A V265 Q269 I270 K273 K297 W299 N387 V414 F415 E416 V42 Q46 I47 K50 K74 W76 N159 V186 F187 E188
BS02 U3O A F229 A231 F247 V316 K344 L366 M370 I374 L377 I395 Y413 F415 F13 A15 F31 V88 K116 L138 M142 I146 L149 I167 Y185 F187
External links
PDB RCSB:8caa, PDBe:8caa, PDBj:8caa
PDBsum8caa
PubMed36988034
UniProtQ15561|TEAD4_HUMAN Transcriptional enhancer factor TEF-3 (Gene Name=TEAD4)

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