Structure of PDB 8ca1 Chain A

Receptor sequence
>8ca1A (length=589) Species: 10090 (Mus musculus) [Search protein sequence]
RAESKSFAVGMFKGQLTIDQVFPYPSVLSEEQAQFLKELVGPVARFFEEV
NDPAKNDALEKVEDDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEI
VGMHDLGVSVTLGAHQSIGFKGILLYGTKAQREKYLPRVASGQALAAFCL
TEPSSGSDVASIRSSAIPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTP
IKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVK
VPSENVLGEVGDGFKVAVNILNNGRFGMAATLAGTMKSLIAKAVDHATNR
TQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFKDFQIEAA
ISKIFCSEAAWKVADECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGAND
ILRLFVALQGCMDKGKELTGLGNALKNPFGNVGLLMGEAGKQLRRRTGIG
SGLSLSGIVHPELSRSGELAVQALDQFATVVEAKLVKHKKGIVNEQFLLQ
RLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRE
NMASLQSSPQHQELFRNFRSISKAMVENGGLVTGNPLGI
3D structure
PDB8ca1 Cryo-EM structure of the ACADVL dimer from Mus musculus.
ChainA
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.8.9: very-long-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A R367 Q369 F370 F377 V379 I380 Q436 I437 R300 Q302 F303 F310 V312 I313 Q369 I370
BS02 FAD A F215 T218 G223 S224 W250 S252 F462 D467 I468 Q563 F148 T151 G156 S157 W183 S185 F395 D400 I401 Q496
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0001659 temperature homeostasis
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009062 fatty acid catabolic process
GO:0009409 response to cold
GO:0030855 epithelial cell differentiation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0046322 negative regulation of fatty acid oxidation
GO:0090181 regulation of cholesterol metabolic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0031966 mitochondrial membrane
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ca1, PDBe:8ca1, PDBj:8ca1
PDBsum8ca1
PubMed38177503
UniProtP50544|ACADV_MOUSE Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=Acadvl)

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