Structure of PDB 8c9i Chain A

Receptor sequence
>8c9iA (length=396) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKG
VLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLN
PGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGV
EPKTVHELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGD
DLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHH
RDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAG
SPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRM
CLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
3D structure
PDB8c9i 2.05 Angstrom structure of cytochrome P450 CYP141A1 (Rv3121) from Mycobacterium tuberculosis
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEB A L85 L86 H93 R97 G236 G237 T240 E286 H287 R289 F340 H345 C347 P348 A349 S353 L80 L81 H88 R92 G231 G232 T235 E281 H282 R284 F335 H340 C342 P343 A344 S348
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0036199 cholest-4-en-3-one 26-monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0006707 cholesterol catabolic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c9i, PDBe:8c9i, PDBj:8c9i
PDBsum8c9i
PubMed
UniProtP9WPL7|CP141_MYCTU Putative cytochrome P450 141 (Gene Name=cyp141)

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