Structure of PDB 8c8d Chain A

Receptor sequence
>8c8dA (length=339) Species: 9606 (Homo sapiens) [Search protein sequence]
TCPFYKKIPGTGFTVDAFQYGVVEGCTAYFLTHFHSDHYAGLSKHFTFPV
YCSEITGNLLKNKLHVQEQYIHPLPLDTECIVNGVKVVLLDANHCPGAVM
ILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTTYCSPEYTFP
SQQEVIRFAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVG
MSQEKYKTLQCLNIPEINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKC
GGKYNQILAFRPTGWTHSFTRIADVIPQTKGNISIYGIPYSEHSSYLEMK
RFVQWLKPQKIIPTVNVGTWKSRSTMEKYFREWKLEAGY
3D structure
PDB8c8d Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 44).
ChainA
Resolution1.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U2C A H734 D736 H737 H793 D815 H994 H35 D37 H38 H94 D116 H293
BS02 ZN A H732 H734 H793 D815 H33 H35 H94 D116
BS03 ZN A D736 H737 D815 D37 H38 D116
External links
PDB RCSB:8c8d, PDBe:8c8d, PDBj:8c8d
PDBsum8c8d
PubMed38817593
UniProtQ6PJP8|DCR1A_HUMAN DNA cross-link repair 1A protein (Gene Name=DCLRE1A)

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