Structure of PDB 8c8b Chain A

Receptor sequence
>8c8bA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
TCPFYKKIPGTGFTVDAFQYGVVEGCTAYFLTHFHSDHYAGLSKHFTFPV
YCSEITGNLLKNKLHVQEQYIHPLPLDTECIVNGVKVVLLDANHCPGAVM
ILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTTYCSPEYTFP
SQQEVIRFAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVG
MSQEKYKTLQCLNIPEINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKC
GGKYNQILAFRPTGWTHSNKFTRIADVIPQTKGNISIYGIPYSEHSSYLE
MKRFVQWLKPQKIIPTVNVGTWKSRSTMEKYFREWKLEAGY
3D structure
PDB8c8b Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).
ChainA
Resolution1.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U1L A H734 S735 D736 H737 H793 H35 S36 D37 H38 H94
BS02 ZN A H732 H734 H793 D815 H33 H35 H94 D116
BS03 ZN A H737 D815 H38 D116
External links
PDB RCSB:8c8b, PDBe:8c8b, PDBj:8c8b
PDBsum8c8b
PubMed38817593
UniProtQ6PJP8|DCR1A_HUMAN DNA cross-link repair 1A protein (Gene Name=DCLRE1A)

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