Structure of PDB 8c80 Chain A

Receptor sequence
>8c80A (length=184) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TTEPVKDHRRRRAAAIISHVEPETFEDENDQQLLPNMNATWVDQRGAWII
HVVIIILLKLFYNLFPGVTTEWSWTLTNMTYVIGSYVMFHLIKGTPFDFN
GGAYDNLTMWEQIDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSW
NCFLTTFGAVVPKLPVTHRLRISIPGITGRAQIS
3D structure
PDB8c80 Structure of the ceramide-bound SPOTS complex.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z8A A W79 H89 M117 Y119 M126 I130 P134 M147 W41 H51 M79 Y81 M88 I92 P96 M109
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006672 ceramide metabolic process
GO:0006986 response to unfolded protein
GO:0030148 sphingolipid biosynthetic process
GO:0090155 negative regulation of sphingolipid biosynthetic process
GO:0090156 intracellular sphingolipid homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0017059 serine palmitoyltransferase complex

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Cellular Component
External links
PDB RCSB:8c80, PDBe:8c80, PDBj:8c80
PDBsum8c80
PubMed37794019
UniProtP53224|ORM1_YEAST Protein ORM1 (Gene Name=ORM1)

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