Structure of PDB 8c6d Chain A

Receptor sequence
>8c6dA (length=240) Species: 39054 (Enterovirus A71) [Search protein sequence]
TSDESMIETRCVLNSHSTAETTLDSFFSRAGLVGEIDLPLEGTTNPNGYA
NWDIDITGCAQMRRKVELFTYMRFDAEFTFVACTPTGQVVPQLLQYMFVP
PGAPIPESRESLAWQTATNPSVFVKLTDPPAQVSVPFMSPASAYQWFYDG
YPTFGEHKQEKDLEYGACPNNMMGTFSVRTVGSSKSKYALVVRIYMRMKH
VRAWIPRPMRNQNYLFKANPNYAGDSIKPTGTSRNAITTL
3D structure
PDB8c6d Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SQS A I111 D112 I113 F135 F137 Y153 F155 P177 V179 V192 M195 Y201 W203 N228 F233 I54 D55 I56 F78 F80 Y96 F98 P120 V122 V135 M138 Y144 W146 N171 F176
External links
PDB RCSB:8c6d, PDBe:8c6d, PDBj:8c6d
PDBsum8c6d
PubMed36778240
UniProtQ66479|POLG_HE71M Genome polyprotein

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