Structure of PDB 8c58 Chain A

Receptor sequence

>8c58A (length=376) Species: 272633 (Malacoplasma penetrans HF-2) [Search protein sequence]

KIKVIKVFEAFAGIGSQFKALKNIARSKNWEIQHSGMVEWFVDAIVSYVA
IHSKNFNPKIERLDRDILSISNDSKMPISEYGIKKINNTIKASYLNYAKK
HFNNLFDIKKVNKDNFPKNIDIFTYSFPCQDLSVQTRSGLLWEIERILEE
IKNSFSKEEMPKYLLMENVKNLLSHKNKKNYNTWLKQLEKFGYKSKTYLL
NSKNFDNCQNRERVFCLSIRDDYLEKTGFKFKELEKVKNPPKKIKDILVD
SSNYKYLNLNKYETTTFRETKSNIISRPLKNYTTFNSENYVYNINGIGPT
LTASGANSRIKIETQQGVRYLTPLECFKYMQFDVNDFKKVQSTNLISENK
MIYIAGNSIPVKILEAIFNTLEFVNN

3D structure

PDB

8c58 CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI.

Chain

Resolution

1.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E184 R228 R230 T287 S289 F302 P316 T317 T319 A320 S321 G322 G373	E167 R211 R213 T270 S272 F285 P299 T300 T302 A303 S304 G305 G356
BS02	dna	A	H192 T301 F302 S304 E305 R326 N366	H175 T284 F285 S287 E288 R309 N349
BS03	SAM	A	F17 A18 G19 I20 S22 Q23 E45 W46 F112 D113 N374 S375	F11 A12 G13 I14 S16 Q17 E39 W40 F106 D107 N357 S358

Gene Ontology

	Molecular Function
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0008168	methyltransferase activity

	Biological Process
GO:0009307	DNA restriction-modification system
GO:0032259	methylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8c58, PDBe:8c58, PDBj:8c58
PDBsum	8c58
PubMed	38966999
UniProt	Q8EVR5

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