Structure of PDB 8c57 Chain A

Receptor sequence

>8c57A (length=374) Species: 272633 (Malacoplasma penetrans HF-2) [Search protein sequence]

KIKVIKVFEAFAGIGSQFKALKNIARSKNWEIQHSGMVEWFVDAIVSYVA
IHSKNFNPKIERLDRDILSISNDSKMPISEYGIKKINNTIKASYLNYAKK
HFNNLFDIKKVNKDNFPKNIDIFTYSFPCQDLSVTRSGLLWEIERILEEI
KNSFSKEEMPKYLLMENVKNLLSHKNKKNYNTWLKQLEKFGYKSKTYLLN
SKNFDNCQNRERVFCLSIRDDYLEKTGFKFKELEKVKNPPKKIKDILVDS
SNYKYLNLNKYETTTFRETKSNIISRPLKNYTTFNSENYVYNINGIGPTL
TASGANSRIKIETQQGVRYLTPLECFKYMQFDVNDFKKVQSTNLISENKM
IYIAGNSIPVKILEAIFNTLEFVN

3D structure

PDB

8c57 CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI.

Chain

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E184 N227 R228 R230 T287 S289 F302 P316 T317 T319 A320 S321 G322 G373	E166 N209 R210 R212 T269 S271 F284 P298 T299 T301 A302 S303 G304 G355
BS02	dna	A	S191 H192 T300 T301 F302 N303 S304 E305 R326 N366	S173 H174 T282 T283 F284 N285 S286 E287 R308 N348
BS03	SAM	A	F17 A18 G19 I20 S22 E45 W46 F112 D113 N374 S375 I376	F11 A12 G13 I14 S16 E39 W40 F106 D107 N356 S357 I358

Gene Ontology

	Molecular Function
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0008168	methyltransferase activity

	Biological Process
GO:0009307	DNA restriction-modification system
GO:0032259	methylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8c57, PDBe:8c57, PDBj:8c57
PDBsum	8c57
PubMed	38966999
UniProt	Q8EVR5

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